Gastroretentive dosage forms have potential for use as controlled-release drug delivery systems. Multiple unit systems avoid the ‘all-or-none’ gastric emptying nature of single unit systems. A type of multi-unit floating ziprasidone HCL Monohydrate microspheres was prepared by the ionotropic gelation method with NaHCO3 as gas-forming agents being used as gas-forming agent and Eudragit L-100 and Eudragit S-100 as polymer. The solution was dropped to 1% CaCl2 solution containing 10% acetic acid for CO2 gas and gel formation. The effects of gas-forming agents on bead size and floating properties were investigated. As gas-forming agents increased, the size and floating properties increased. Bead porosity and volume average pore size, as well as the surface and cross-sectional morphology of the beads were examined with Scanning Electron Microscopy. The micromeritic properties of microspheres were found to be much improved. In-vitro drug release studies were performed and drug release kinetics were evaluated using the linear regression method.
Miss Muttepawar Supriya Shridharrao Old Sarafa Line, KandharTq- Kandhar, Dst- Nanded.Educational Qualification :Degree Percentage University/Bored Year of PassingM.PHARM.2nd 8.38 S.R.T.M.U. NANDED. 2014M.PHARM.1st 8.90 S.R.T.M.U. NANDED. 2013B.PHARM. 76% S.R.T.M.U. NANDED. 2012.
Number of Pages:
LAP LAMBERT Academic Publishing
Microspheres, Drug delivery systems, Floating Microspheres, Gastroretentive, gas-forming, scanning electron microscopy, IN-VITRO, drug release kinetics
MEDICAL / Pharmacology