Medicinal chemistry is a scientific discipline of chemistry and pharmacology. Isoxazole is an azole with an oxygen atom next to the nitrogen. It is also the class of compounds containing this ring. Isoxazolyl is the univalent radical derived from isoxazole. Isoxazole rings are found in some natural products, such as ibotenic acid and muscimol. Isoxazoles also form the basis for a number of drugs, including the COX-2 inhibitor valdecoxib and a neurotransmitter agonist AMPA. An isoxazolyl group is found in many beta-lactamase-resistant antibiotics, such as cloxacillin, dicloxacillin and flucloxacillin. Leflunomide is an isoxazole-derivative.The work on new isoxasole derivatives are establish how a substance operates in the body and its suitability for use as a drugs.
S. A. Joshi
Dr.S.A.Joshi working as assistant professor in M.N.Science College, Visnagar. Other two author Dr.K.V.Goswami working as assistant professor in The H.N.S.B.Ltd Science College, Himatnaga, and Dr.Rinku.P.Patel working in Bhavans Science College, Dakor.
K. V. Goswami
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LAP LAMBERT Academic Publishing
Isoxazole, preparation, derivatives, Acetamide, Spectroscopic Analysis, Biological evolution
SCIENCE / Chemistry / Organic