978-613-7-32745-6

Cancer chemotherapy and nephrotoxicity

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Summary:

Doxorubicin (Dox) is an anthracycline glycoside antibiotic that possesses a potent and broad spectrum anti-tumor activity against variety of human solid tumors and hematological malignancies. However its use in chemotherapy has been limited largely due to its diverse toxicities, including cardiovascular, renal, hepatic, hematological and testicular toxicity.Doxorubicin induces changes in the renal tissue of rats which includes increased glomerular capillary permeability and tubular atrophy. Although the exact mechanism of Dox-induced nephrotoxicity remains unknown, it is believed to be mediated through multifactorial mechanisms including free radical formation, iron dependent oxidative damage of biological macromolecules and membrane lipid peroxidation.

Author:

Marwa Refaie

Biographie:

Marwa Refaie - Lecturer Assistant , MTI.

Number of Pages:

120

Book language:

English

Published On:

2019-10-10

ISBN:

978-613-7-32745-6

Publishing House:

LAP LAMBERT Academic Publishing

Keywords:

Cancer, Chemotherapy, Nephrotoxicity

Product category:

MEDICAL / General