Study of Tumor Markers in the Evaluation of Malignant Pleural Effusion

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Pleural effusion (PE) is a common diagnostic problem and encountered as a complication of many diseases (Ghayumi, 2005). It is a common occurrence in the practice of pulmonologists. The etiology of an effusion can be established in the majority of cases with a careful history, a physical examination, and an evaluation of the pleural fluid including fluid cultures, cytology, and testing for tuberculosis, such as the measurement of adenosine deaminase (ADA) levels (Reaz Fatema, 2009). Approximate annual incidence of malignant pleural effusions in the United States is 200,000 among which due to Lung lesion- 60,000, Breast- 50,000, Lymphoma- 40,000, and other – 50,000 (Light RW, 2006) respectively. A primary pleural tumor is always a mesothelioma. Metastasis occurs commonly from bronchial, breast, stomach and ovarian carcinoma (Chernow B, Sahn SA 1977). Almost any other malignant neoplasm may occasionally metastasize to pleura, while lymphoma may cause effusion without necessarily causing pleural infiltration (Harrison EG et al. 1973).


Mohammad Mesbahuzzaman


Born in Dhaka in 1971 in a Muslim family. Studied in Chittagong University School & College. Graduated in Medicine from Bangladesh Medical College in 1998. Completed M.D. in Pathology from Sir Salimullah Medical College in 2011. Working as a Lecturer in Gulf Medical University in the department of Biomedical Sciences. Lives in Sharjah, UAE.

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Scholars' Press


incidence, Pleural effusion, Etiology, Effusion, Thoracentesis, Cytology of pleural fluid, Pleural Biopsy, Pathological Consideration, Effusion in the absence of cancer, Effusion in the presence of cancer, Tumor Marker

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MEDICAL / General