Perampanel-induced weight gain depends

on level of intellectual disability and its serum concentration

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Body weight (BW) gain may be induced by perampanel (PER) administration, similar to the well-known adverse effects of valproic acid and gabapentin. Intellectual disability (ID) and serum PER concentration may be risk factors of BW gain. This study investigated how ID and serum PER concentration are associated with PER-induced BW gain. Subjects were 76 patients with epilepsy (41 men, aged 16 to 70 years). All patients were divided by intelligence quotient (IQ) into no ID (IQ ≥70, n = 24), mild to moderate ID (70> IQ ≥35, n = 31), and severe to profound ID (IQ <35, n = 21) groups. BW was measured before and 2, 4, 6, and 12 months after initiation of PER treatment, and serum PER concentration at 12 months. The mild to moderate ID group gained more BW than the no ID group, suggesting that PER-induced food intake was greater due to weaker behavioral control in the mild to moderate ID group. The present study suggests a linear correlation between serum PER concentration and BW change.


Hirotaka Iwaki


Hirotaka Iwaki: North Tohoku Epilepsy Center, Minato Hospital, Hachinohe, Aomori, Japan; Department of Epileptology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.

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Publishing House:

LAP LAMBERT Academic Publishing


Perampanel, body weight, intellectual disability, Antiepileptic drug

Product category:

MEDICAL / General