Transdermal drug delivery system is a self contained, discrete pharmaceutical dosage form which when applied to the intact skin, delivers the active ingredient through the skin at a control rate into the systemic circulation. Microemulsion (MEs) is one of the approaches used to enhance drug solubility and bioavailability. Irbesartan, a poorly water soluble drug, has been found amongst other antihypertensive agents to offer advantages in safety and tolerability. Irbesartan has been found to have inter and intra patient variability and its plasma level has been reported not to increase proportionally with the dose following oral administration. The book Transdermal delivery of irbesartan: Microemulsion as a delivery system is aimed at investigating the transdermal delivery of irbesartan using microemulsion. The findings of this present investigation suggest that microemulsion could act as a good carrier for transdermal delivery of irbesartan. The work is considered to be very significant to students of medicine and pharmacy and could also act as a guide to researchers and scientists whose interest are in techniques employed to improve drug delivery.
Chinwe Mercy Onah
Dr. C. M. Onah and Prof. C. J. Mbah are lecturers with the Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Enugu State, Nigeria. Both are researchers in the area of pharmaceutical analysis and drug delivery systems.
Chika J. Mbah
Number of Pages:
LAP LAMBERT Academic Publishing
Irbesartan, Microemulsion, skin permeatiom, Pharmacokinetics
MEDICAL / Pharmacology