Formulation and Evaluation of Berberine Nanogel

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The present study aims to develop and evaluate the permeation as well as anti-microbial activity of developed nanogel of berberine. The incorporation of berberine inside a nanogel should improve berberine stability and permeability. Berberine is a natural polyphenolic agent with promising anti- inflammatory and anti-microbial activity. However, the therapeutic efficacy was challenged in clinical trials mostly due to its low solubility. We design berberine loaded carbopol-934 nanogel to make it stable and substantially enhances cellular permeability. Pseudoternary phase diagram is constructed to obtain the nanoemulsion region. It is popular amongst the general population in regions all over the world. Carbopol-934 is added as gelling agent. Oil in water nanoemulsion was prepared by the self-nanoemulsification method, using Tween 80 and Carbitol as surfactant and cosurfactant using an oil phase of oleic acid. Evaluation of the nanoemulsion included analysis of particle size, polydispersity index, zeta potential, physical stability, and morphology. A modified vertical Franz diffusion cell and diffusion membrane were used to study the in vitro permeation.


Sanjar Alam


Dr. Sanjar Alam is young and dynamic faculty cum researcher having more than twelve year of teaching and research experience and published more than thirty research paper and review article in national and international journal of repute. He did his Ph.D. from Department of Pharmaceutics Jamia Hamdard. Currently working as Associate Professor.

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LAP LAMBERT Academic Publishing


Berberine, Pseudo ternary phase diagram, nanoemulsion, Transdermal flux, Accelerated stability studies

Product category:

EDUCATION / Administration