Bipolar disorder is characterized by a switch between manic and depressive episodes. Recently, Freund and colleagues developed a lentiviral-induced animal model that is able to model both phases in one animal. By manipulating the dopamine D1 receptor (D1R) expression in the medial prefrontal cortex (mPFC) of rats, they were able to induce either mania- or depressive-like behavior one after the other. Lentiviral overexpression of the D1R in rats PFC induced mania-like behavior (ON state), whereas termination of this D1R overexpression (OFF state) resulted in depressive-like behavior. For a better understanding of the neurobiology connected to the observed behavior, this study investigated dopamine D2 receptor (D2R) alterations in the rat brain accompanied by induced mania- or depressive-like behavior. To obtain a first insight view on the impact of this D1R manipulation, the D2R properties were examined as a possible downstream target in several bipolar associated brain regions, like the PFC, striatum, nucleus accumbens, hippocampus and ventral tegmental area.
Dominik Beyer studied Biology at the Johannes Gutenberg-University in Mainz and received his Master of Science in Neurobiology at the Eberhard Karls University in Tübingen. Since 2017 he is working on his PhD with Prof. Freund at the Ruhr-University Bochum. He is supported with a doctoral fellowship of the Studienstiftung des deutschen Volkes.
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psychiatry, bipolar disorder, viral construct, dopamine D1 receptor, dopamine D2 receptor, positron-emission tomography, raclopride
SCIENCE / Biology