978-620-2-68142-1

HLA and BCG Vaccination

Regular price
€54,90
Sale price
€54,90
Regular price
Sold out
Unit price
per 
Shipping calculated at checkout.

Summary:

We attempt to study the immunogenetic of BCG in vaccinated Healthcare workers (HCWs) in Khartoum, 137 HCWs were selected for this study. It was found that alleles associated with TB-exposed group DRB1*0701, DRB1*1501, DQB1*0501, and DQB1*0301. DRB1*0701 and DQB1*0301 with high frequency among strong TST-positive group, DRB1*0701, and DQB1*0601 alleles were high frequency among moderate TST - positive group and DRB1*0701, DRB1*1501, DQB1*0601 alleles were high frequency among TST- negative group. Some of these alleles (DRB1*1501, DQB1*0701, DQB1*0301 were shown exclusively in TB-exposed subjects (100%). It seems that they act as susceptibility genes to TB. DRB1*0201 and DQB1*01 and DRB1*0301 alleles were found to be associated with the control group. This study group was categorized into three sub-groups based on the ethnic group: Nilotic, Nubian, and Kordufan and Darfur groups. DRB1*03, DRB1*13, DQB1*01, DQB1*04, DQB1*02, and DQB1*06 were exclusively found in the Nilotic tribes (100%). While DRB1*07 was exclusively found in Kordufan and Darfur tribes (100%), the DRB1*15 allele was higher (53.3%) among Nubian tribes.

Author:

Hanaa Mahmoud

Biographie:

I am PhD holder in the field of Biology (Immunology), I have many published pieces of research, I have been teaching biology for almost ten years.

Author:

Abdelrahim El Hussien

Biographie:

Number of Pages:

112

Book language:

English

Published On:

2020-07-17

ISBN:

978-620-2-68142-1

Publishing House:

LAP LAMBERT Academic Publishing

Keywords:

HLA, TB, BCG, Tuberculin Skin Test.

Product category:

SCIENCE / Biology