We attempt to study the immunogenetic of BCG in vaccinated Healthcare workers (HCWs) in Khartoum, 137 HCWs were selected for this study. It was found that alleles associated with TB-exposed group DRB1*0701, DRB1*1501, DQB1*0501, and DQB1*0301. DRB1*0701 and DQB1*0301 with high frequency among strong TST-positive group, DRB1*0701, and DQB1*0601 alleles were high frequency among moderate TST - positive group and DRB1*0701, DRB1*1501, DQB1*0601 alleles were high frequency among TST- negative group. Some of these alleles (DRB1*1501, DQB1*0701, DQB1*0301 were shown exclusively in TB-exposed subjects (100%). It seems that they act as susceptibility genes to TB. DRB1*0201 and DQB1*01 and DRB1*0301 alleles were found to be associated with the control group. This study group was categorized into three sub-groups based on the ethnic group: Nilotic, Nubian, and Kordufan and Darfur groups. DRB1*03, DRB1*13, DQB1*01, DQB1*04, DQB1*02, and DQB1*06 were exclusively found in the Nilotic tribes (100%). While DRB1*07 was exclusively found in Kordufan and Darfur tribes (100%), the DRB1*15 allele was higher (53.3%) among Nubian tribes.
I am PhD holder in the field of Biology (Immunology), I have many published pieces of research, I have been teaching biology for almost ten years.
Abdelrahim El Hussien
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LAP LAMBERT Academic Publishing
HLA, TB, BCG, Tuberculin Skin Test.
SCIENCE / Biology